Application of three HPV nucleic acid test reagents in the screening of
high-risk HPV infection
- Lanxin Peng,
- Peng Zhao
, - Hongju Zhou,
- Lei REN,
- Zhuojun OU,
- Yu XIANG
Lanxin Peng
The First Affiliated Hospital of Chongqing Medical University
Author ProfilePeng Zhao
![](https://d197for5662m48.cloudfront.net/assets/icons/omniauth/orcid-ca37582cd91a671ed5cec57770e0e96c01b4b79b8b5b75d8598fc1ddac18c974.svg)
The First Affiliated Hospital of Chongqing Medical University
Author ProfileHongju Zhou
The First Affiliated Hospital of Chongqing Medical University
Author ProfileLei REN
The First Affiliated Hospital of Chongqing Medical University
Author ProfileZhuojun OU
The First Affiliated Hospital of Chongqing Medical University
Author ProfileAbstract
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Objective To analyze the positive detection rate of three HPV
reagents for 14 hr-HPV types. To provide more accurate medical evidence
for the diagnosis of clinical HPV infection. Methods Three HPV
reagents were used to detect HPV typing in the cervical exhaled cells of
678 patients with HPV infection, to compare the consistency between the
detection results and the Sanger sequencing results, then to analyze the
sensitivity and specificity of three detection reagents for 14 hr-HPV.
Results Sensitivity of three HPV nucleic acid detection
reagents: Reagent 1 (58.86%) P<0.001). For HPV16, 18, 31, 39,
52, 56, 66, and 68, there was a statistically significant difference in
the positive rates of the three HPV nucleic acid testing reagents (
P<0.05) Conclusion For HPV 16, 31, 33, 39, 66
and 68, reagent 2 should be used for screening first, for HPV18, 52,
reagent 1 should be used for screening first, reagent 3 should be used
finally to recheck and detect the specifics to ensure the accuracy and
sensitivity of the results.Submission Checks Completed Assigned to Editor
Reviewer(s) Assigned