Long-term cardiovascular events and risk factors in adults sepsis
survivors: A systematic review and meta-analysis
Abstract
Background Hospitalization for sepsis may be associated with an
increased risk for cardiovascular events. We aim to explore the
relationship between sepsis hospitalization and long-term of
cardiovascular events, and describe risk factors for cardiovascular
events in adults sepsis survivors. Methods MEDLINE, EMBASE, Cochrane
Library, Wanfang, and CNKI were searched, from inception to Aug 2023,
and no language limitation. Cumulative incidence and hazard ratios (HRs)
with 95% confidence interval (CI) was used to assess the strength of
the association. Results 25 observational studies were included in this
meta-analysis. The pooled cumulative incidence of major cardiovascular
was 9.0%, myocardial infarction was 2.4%, stroke was 4.9% and
congestive heart failure was 8.6%. Sepsis hospitalization was
associated with a higher long-term risk of major cardiovascular (HR,
1.54; 95% CI 1.32- 1.79), myocardial infarction (HR, 1.41; 95% CI
1.29- 1.54), stroke (HR, 1.45; 95% CI 1.32- 1.60) and congestive heart
failure (HR, 1.51; 95% CI 1.46- 1.56) compared to non-sepsis controls.
Pooled analysis indicate that age≤ 45 years, male gender,
hyperlipidaemia, and some comorbidities were significantly associated
with increased hazards of cardiovascular events. Conclusions Adults
sepsis survivors may be experience a higher hazard of cardiovascular
events compared to non-sepsis controls. And both common cardiovascular
risk factors and sepsis-related variables can significantly increase
this correlation.