This review offers an extensive overview of recent advancements in the development of SACs for electrochemical water splitting. We critically assess the latest research on single-site, dual-site, and alloy SAC configurations, emphasizing their unique structural and electronic properties that enhance the kinetics of hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). Finally, we identify current challenges and future research directions in the field, highlighting the potential of SACs to revolutionize the production of green hydrogen through efficient and sustainable water electrolysis.