Aims: The objective of this study is to describe the disease characteristics of patients with idiopathic inflammatory myopathy (IIM) in the Southern China. Method: The study included patients who were admitted to the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Foshan Hospital of Chinese Medicine, and Jiangmen Wuyi Traditional Chinese Medicine Hospital between 2012 and 2023 and were diagnosed with IIM. Demographic, clinical data, and treatment plans were collected and analyzed. Results: A total of 237 patients were included in the study. Women accounted for 65% of the cases, with an average age of 49±16.19 years and a mean follow-up period of 2.48±5.02 years. The main clinical manifestations were fatigue (67.9%), rash (46.0%), and myalgia (45.6%). Other clinical manifestations were interstitial lung disease (ILD, 33.8%), arthralgia (27.0%), heart valve disease (15.2%). The main complications included hypertension (15.2%), hyperlipidemia (13.1%), and diabetes (11.4%). 21.7% had co-infections, and 5.9% had co-occurring tumors. Anti-nuclear antibody (ANA) was detected in 55.7%. The most frequent myositis-specific antibodies (MSA) were anti-Jo-1 (13.1%). Elevated creatine kinase (CK) accounted for 65%. The most used medications were glucocorticoids (94.5%), hydroxychloroquine (29.5%), and methotrexate (27.8%). Conclusion: This study provides a comprehensive description of the characteristics of IIM in the Southern China. The findings serve as a basis for future clinical research and the development of treatment strategies for IIM.