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Molecular changes in natural antifreeze phenomena and cryopreservation
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  • Lingyu Shi,
  • Chuanbao Zang,
  • Zhicheng Liu,
  • Gang Zhao
Lingyu Shi
University of Science and Technology of China Department of Electronic Engineering and Information
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Chuanbao Zang
Jinan250000China

Corresponding Author:[email protected]

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Zhicheng Liu
Jinan250000China
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Gang Zhao
University of Science and Technology of China Department of Electronic Engineering and Information
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Abstract

In nature, many organisms exhibit remarkable freezing tolerance and employ rich and intriguing physiological strategies to adapt to low-temperature environments. However, cryopreservation techniques face challenges when it comes to freezing and thawing biological tissues and cells, such as cryo-damage caused by crystallization and cell membrane rupture due to osmotic imbalances. In recent years, there has been growing interest in the molecular mechanisms underlying natural freezing tolerance and artificial cryopreservation processes. This review delves into the adaptive mechanisms observed in freeze-tolerant species and hibernating animals, elucidating the significance of specific genes, proteins, and metabolic pathways for survival. Furthermore, we discuss advancements in cryopreservation technologies, highlighting their impacts on cellular and tissue integrity, and analyzes the adaptive regulation of processes like glucose metabolism, miRNA expression, and cryoprotective protein modulation. Finally, future directions for cryopreservation are proposed.
Submitted to Biotechnology and Bioengineering
Submission Checks Completed
Assigned to Editor
Reviewer(s) Assigned
27 Jun 2024Review(s) Completed, Editorial Evaluation Pending
30 Jun 2024Reviewer(s) Assigned
11 Aug 20241st Revision Received
12 Aug 2024Submission Checks Completed
12 Aug 2024Assigned to Editor
12 Aug 2024Review(s) Completed, Editorial Evaluation Pending
12 Aug 2024Reviewer(s) Assigned
13 Aug 2024Editorial Decision: Accept