Abstract
Objective: This study aims to enhance the management of Epstein-Barr
Virus (EBV) infections by analyzing the correlation between laboratory
indicators and clinical manifestations in children, thereby proposing
more precise diagnostic and treatment strategies. Methods: In this
retrospective study included 163 pediatric patients with EBV infections
treated at the Children’s Hospital of Soochow University from December
2017 to December 2019. Data collected through retrospective analysis
included gender, age, clinical symptoms, signs, liver function tests,
T-cell subset distribution, EBV-DNA copy numbers in plasma and whole
blood, and treatment outcomes. Patients were grouped based on EBV copy
numbers and hospital stay duration to compare clinical indicators across
different groups. Results: The dichotomous results of EBV plasma level
showed that the two groups of children were significantly different in
the number of days of fever (p= 0.0373), platelet count (p= 0.018), ALT
(p= 0.0299), immunoglobulin IgM (p= 0.0323), IgG (p= 0.0299), TBiL (p=
0.0037), LDH (p< 0.001), number of CD19+ cells (p= 0.0204) and
length of hospital stay (p< 0.001) were significantly
different, indicating that EBV plasma levels may be correlated with
these characteristic variables.The dichotomous results of the length of
hospital stay showed that the two groups were significantly increased in
tonsil enlargement (p= 0.0024), platelet count (p= 0.00449), LDH (p=
0.0394), CD3+ cell count (p= 0.0383), and ferritin (p= 0.0106) and EBV
plasma levels (p< 0.001) were significantly different, This
suggests a potential correlation between EBV plasma levels and these
clinical indicators. Conclusion: Variations in platelet counts and
lactate dehydrogenase (LDH) levels in children with EBV infections may
serve as indicators of clinical outcomes.