Synthetic Investigation toward Acyl Group-Free Escin Derivatives
- Jian-Song Sun,
- Xin Lv,
- Jinxi Liao,
- Zhen-Qiang Li,
- Zhi-Sheng Xiong,
- Qi-Shuang Yin,
- Hui Liu,
- Yuan-Hong Tu
Abstract
With protoescigenin as starting material and through orchestrated
application of Yu and Schmidt glyco-sylation protocols, the synthesis of
acyl group-free escin derivatives were achieved for the first time. As
the undesired non-specific toxicity, originated from the existence of
acyl groups on aglycone, prohibits the wide application of escins, the
established strategies toward non-acylated protoescigenin-type sap-onins
would dramatically ease the access to escin derivatives dispense of acyl
groups, thereby speeding up the pace of pharmaceutical use of these
valuable compounds.21 Jul 2024Submitted to Chinese Journal of Chemistry 23 Jul 2024Submission Checks Completed
23 Jul 2024Assigned to Editor
23 Jul 2024Review(s) Completed, Editorial Evaluation Pending
24 Jul 2024Reviewer(s) Assigned
07 Aug 2024Editorial Decision: Revise Minor
13 Aug 20241st Revision Received
13 Aug 2024Submission Checks Completed
13 Aug 2024Assigned to Editor
13 Aug 2024Review(s) Completed, Editorial Evaluation Pending
14 Aug 2024Editorial Decision: Accept