The purpose is to analyze the clinical features and mortality rates of Chinese acute leukemia patients affected by COVID-19 infection. We retrospectively analyzed the clinical characteristics of acute leukemia patients with COVID-19 infection in Henan Province, China, from December 1, 2022, to January 31, 2023. Our study included 100 cases of acute leukemia with COVID-19 infection. The median age was 49.5 years old (58% male and 42% female). Patients with acute myeloid leukemia were 76%, and 24% were acute lymphoblastic leukemia.86% of patients were asymptomatic; 35% of patients received antibiotic treatment, and 25% received antiviral treatment. For the first time, we analyzed the factors affecting the days of nucleic acid cycle threshold (CT) (CT≤36) in acute leukemia patients infected with COVID-19; the days in severe cases and dead patients was significantly longer. We found that in patients with neutropenia who were receiving antibiotic treatment the days was significantly longer, whereas in patients receiving antiviral treatment or delayed treatment this number was shorter. All patients were followed up for three months, and the overall mortality rate was 6%. Although multivariate analysis showed that no death related factor, univariate analysis showed that neutropenia was the main factor affecting mortality in patients infected with COVID-19. Early application of antiviral drug shorten the number of days of COVID-19 nucleic acid CT value≤36 in AL patients infected with COVID-19, which may further reduce the proportion of patients with severe symptoms or death.