The association between reproductive outcomes and serum uric acid in
women with polycystic ovary syndrome undergoing freeze-all embryo
transfer after assisted reproductive technology: a cohort study
Abstract
OBJECTIVE: To investigate how serum uric acid (SUA) influences
the reproductive outcomes among women with polycystic ovary syndrome
(PCOS) undergoing freeze-all strategy. DESIGN: Retrospective
cohort study. Setting: Reproductive center in a tertiary
hospital in China. Population: 1115 women aged 20-40 years with
PCOS were included. Method: The entire population was
categorized into four groups based on SUA quartiles, logistic regression
analysis was conducted to determine odds ratios (ORs) for reproductive
and pregnancy complications, adjusting for potential confounders.
Main Outcome Measures: Primary outcome was live birth, defined
as the gestational age ≥28 weeks or weighing ≥ 1000 grams.
RESULTS: In quartiles of SUA levels, there was no significant
difference in the live birth rate from the lowest quartile (Q1: 57.9%)
to the highest (Q4: 56.6%) (adjusted OR 1.08, 95% CI, 0.74-1.57,
P=0.58). Similarly, SUA showed no significant effect on biochemical and
clinical pregnancy rate, or miscarriage rate (p>0.05). Women
in quartile 4 had added the risk of gestational diabetes mellitus (GDM)
(adjusted OR 3.87, 95% CI 1.77-8.47), gestational hypertension (GH)
(adjusted OR 3.82, 95% CI 1.16-12.58) compared with quartile 1. Women
in quartile 4 also had an increased probability of preterm birth and low
birth weight(adjusted OR 2.24, 95% CI 0.90-5.59;adjusted OR 3.58,
95% CI 0.88-14.56, respectively). CONCLUSION: No significant
correlation was found between SUA and live birth in women with PCOS
undergoing freeze-all strategy. However, elevated SUA increased the risk
of GH, GDM and tended to increase the risk of preterm labor and LBWI.