Abstract
Objective: The potential risk of inducing ventricular
arrhythmias was explored by employing Pulsed Field Ablation (PFA)
through the administration of both monophasic and biphasic waveform
deliveries. Methods: Pulsed Field Ablation (PFA) was applied to
specific locations in the right ventricle (RV, n=5 sites) in swine
(n=2), utilizing identical settings with consistent amplitude, pulse
width, and number of pulses for both monophasic and biphasic waveforms.
PFA deliveries were precisely timed in 10-milisecond intervals across
the entire T wave. Results: Using monophasic waveforms,
ventricular fibrillation (VF) was induced 7/7 times when PFA pulses were
delivered during the T wave. Biphasic waveforms resulted in no
ventricular arrhythmias when PFA was delivered across the entire
duration of T wave. Conclusions: Our findings indicate that VF
can be consistently induced with monophasic pulse waves, but not with
biphasic pulse waves in a porcine model.