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Exploring Behavioral Patterns in Youth Predisposed to Bipolar Disorder and the Role of Interpersonal Trauma Using the Adolescent Brain Cognitive Development (ABCD) Dataset
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  • Christina Ghaleb,
  • Danielle Penney,
  • Katie M. Lavigne,
  • Delphine Raucher-Chene
Christina Ghaleb
Douglas Research Centre
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Danielle Penney
Douglas Research Centre
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Katie M. Lavigne
Douglas Research Centre
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Delphine Raucher-Chene
Douglas Research Centre

Corresponding Author:[email protected]

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Abstract

Introduction: Bipolar Disorder (BD) is a severe, persistent disorder that causes functional impairment. Besides heritability, environmental factors, such as traumatic experience, impact the development of BD. Little is known about the early developmental signs of this disorder; therefore, this study aims to look at the impact of interpersonal trauma on the early developmental signs of BD. Specifically, differences in psychopathological behaviors were investigated between (1) at-risk children to controls and (2) at-risk children who experienced an interpersonal traumatic event to those who did not. Methods: Using the Adolescent Brain Cognitive Development (ABCD) dataset, participants with a first-degree relative with BD were identified (N at-risk=625) and matched on sex and age to a control group (N control=625). The Kiddie Schedule for Affective Disorders and Schizophrenia (KSADS) was used to assess interpersonal trauma and psychopathological symptoms. The trauma (N trauma=198) and no trauma subgroups (N no trauma=428) were built from the at-risk population. Group comparison was conducted on depressive, manic, and anxiety symptoms. Results: Compared to controls, at-risk children exhibited a significantly greater number of manic symptoms at baseline, and depression and anxiety symptoms at two-year follow-up. No significant differences were found between the trauma and no-trauma groups at either baseline or follow-up. Discussion: These results confirm the presence of early symptoms in at-risk children, in line with the staging model of BD. Extended longitudinal research is needed to further investigate the potential specific role of trauma on its early behavioral patterns.
04 Oct 2024Submitted to Early Intervention in Psychiatry
06 Oct 2024Submission Checks Completed
06 Oct 2024Assigned to Editor
06 Oct 2024Review(s) Completed, Editorial Evaluation Pending
07 Oct 2024Reviewer(s) Assigned