Toxocara infection and childhood allergic asthma, a Case-Control Study
in Boyer Ahmad County; southwest Iran
- Ali Pouryousef,
- Samer Mehrabi,
- Reza Abbasi,
- AbdoAli Moshfe,
- Fattaneh Mikaeili,
- Zahra Rezaei,
- Davoud Rostamzadeh,
- Amin Alah Saadat,
- Nasir Arefkhah
Fattaneh Mikaeili
Shiraz University of Medical Sciences School of Medicine
Author ProfileZahra Rezaei
Shiraz University of Medical Sciences Professor Alborzi Clinical Microbiology Research Center
Author ProfileAbstract
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Introduction: Evidence from multiple data sources indicates
that toxocariasis might play a role in the allergic asthma in children.
This case-control study investigated the connection between
Toxocara seropositivity and allergic asthma. It also sought to
identify the conventional risk factors associated with both asthma and
Toxocara infection. Methods: In this case-control study,
200 allergic asthma children, and 208 children with no history of
allergic asthma were included as the healthy group. Sera samples were
examined for specific anti-Toxocara IgG antibodies using a serological
assay. Results: The overall prevalence of toxocariasis was
6.9% among children. The seroprevalence of toxocariasis in asthmatic
children and healthy children was 8% and 5.8% respectively, with no
significant difference (P-value= 0.373). In subgroup analyses based on
sociodemographic, Toxocara infection seropositivity was significantly
associated with two independent variables, including the father’s
occupation (P-value = 0.017) and soil contact in asthmatic children
(P-value = 0.033). Conclusions: Our results showed a higher
prevalence of Toxocara infection in asthmatic children compared to
healthy controls, but this difference was not statistically significant.
To gain a clearer understanding and comparison of Toxocara infection
rates between asthmatic and healthy children, additional comprehensive
studies with larger sample sizes and diverse detection methods using
different antigenic sources are required.01 Oct 2024Submitted to Parasite Immunology 07 Oct 2024Submission Checks Completed
07 Oct 2024Assigned to Editor
07 Oct 2024Review(s) Completed, Editorial Evaluation Pending
15 Oct 2024Reviewer(s) Assigned
04 Nov 2024Editorial Decision: Revise Minor