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Toxocara infection and childhood allergic asthma, a Case-Control Study in Boyer Ahmad County; southwest Iran
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  • Ali Pouryousef,
  • Samer Mehrabi,
  • Reza Abbasi,
  • AbdoAli Moshfe,
  • Fattaneh Mikaeili,
  • Zahra Rezaei,
  • Davoud Rostamzadeh,
  • Amin Alah Saadat,
  • Nasir Arefkhah
Ali Pouryousef
Sabzevar University of Medical Sciences
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Samer Mehrabi
Yasuj University of Medical Sciences
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Reza Abbasi
Yasuj University of Medical Sciences
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AbdoAli Moshfe
Yasuj University of Medical Sciences
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Fattaneh Mikaeili
Shiraz University of Medical Sciences School of Medicine
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Zahra Rezaei
Shiraz University of Medical Sciences Professor Alborzi Clinical Microbiology Research Center
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Davoud Rostamzadeh
Yasuj University of Medical Sciences
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Amin Alah Saadat
Yasuj University of Medical Sciences
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Nasir Arefkhah
Yasuj University of Medical Sciences

Corresponding Author:[email protected]

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Abstract

not-yet-known not-yet-known not-yet-known unknown Introduction: Evidence from multiple data sources indicates that toxocariasis might play a role in the allergic asthma in children. This case-control study investigated the connection between Toxocara seropositivity and allergic asthma. It also sought to identify the conventional risk factors associated with both asthma and Toxocara infection. Methods: In this case-control study, 200 allergic asthma children, and 208 children with no history of allergic asthma were included as the healthy group. Sera samples were examined for specific anti-Toxocara IgG antibodies using a serological assay. Results: The overall prevalence of toxocariasis was 6.9% among children. The seroprevalence of toxocariasis in asthmatic children and healthy children was 8% and 5.8% respectively, with no significant difference (P-value= 0.373). In subgroup analyses based on sociodemographic, Toxocara infection seropositivity was significantly associated with two independent variables, including the father’s occupation (P-value = 0.017) and soil contact in asthmatic children (P-value = 0.033). Conclusions: Our results showed a higher prevalence of Toxocara infection in asthmatic children compared to healthy controls, but this difference was not statistically significant. To gain a clearer understanding and comparison of Toxocara infection rates between asthmatic and healthy children, additional comprehensive studies with larger sample sizes and diverse detection methods using different antigenic sources are required.
01 Oct 2024Submitted to Parasite Immunology
07 Oct 2024Submission Checks Completed
07 Oct 2024Assigned to Editor
07 Oct 2024Review(s) Completed, Editorial Evaluation Pending
15 Oct 2024Reviewer(s) Assigned
04 Nov 2024Editorial Decision: Revise Minor