The effects and mechanisms of double heterogeneous calcium alginate
scaffold in promoting the surface shape recovery and internal
osteogenesis of alveolar bone
- Zhanchao Ye,
- songxia ke,
- xiaohui sun,
- jing qian,
- ziqing zhou,
- minhong lin,
- baoying he,
- renze shen
Zhanchao Ye
School of Stomatology, Fujian Medical University, Department of Stomatology, Zhongshan Hospital of Xiamen University
Author Profilesongxia ke
School of Stomatology, Fujian Medical University, Department of Stomatology, Zhongshan Hospital of Xiamen University
Author Profilexiaohui sun
College of Chemical Engineering, Huaqiao University
Author Profilejing qian
College of Chemical Engineering, Huaqiao University,Department of laboratory, Putian Center for Disease Prevention and Control
Author Profileziqing zhou
School of Stomatology, Fujian Medical University, Department of Stomatology, Zhongshan Hospital of Xiamen University
Author Profileminhong lin
School of Stomatology, Fujian Medical University, Department of Stomatology, Zhongshan Hospital of Xiamen Universit
Author Profilebaoying he
Department of Oncology, Zhongshan Hospital of Xiamen University
Author Profilerenze shen
School of Stomatology, Fujian Medical University, Department of Stomatology, Zhongshan Hospital of Xiamen University
Corresponding Author:[email protected]
Author ProfileAbstract
In this work, double-layer heterogeneous calcium alginate scaffolds were
designed for alveolar bone defects where the outer layer featured high
hardness and slow degradation, and the inner layer characterized by
large pores and rapid degradation. The morphology of the calcium
alginate scaffold was akin to that of bone defects, and its direct
implantation reduced the operation time. A higher concentration of
calcium alginate resulted in smaller pores and slower degradation.
Calcium alginate can promote the formation of mineralized nodules and
the expression of genes related to mineralization without inducing
cytotoxic effects. It also promoted the expression of cellular
inflammatory factors, potentially through the TLR4 pathway. In vivo
studies confirmed that calcium alginate did not promote the aggregation
of inflammatory cells nor the expression of inflammatory factors. In
conclusion, the scaffold's characteristics of high surface hardness and
slow degradation were beneficial for surface osteogenesis and
maintaining the defect's shape and osteogenic space. Conversely, rapid
internal degradation favors the formation of bone tissue.09 Oct 2024Submitted to Biotechnology Journal 12 Oct 2024Submission Checks Completed
12 Oct 2024Assigned to Editor
12 Oct 2024Review(s) Completed, Editorial Evaluation Pending
12 Oct 2024Reviewer(s) Assigned
31 Oct 2024Editorial Decision: Revise Major