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The effects and mechanisms of double heterogeneous calcium alginate scaffold in promoting the surface shape recovery and internal osteogenesis of alveolar bone
  • +5
  • Zhanchao Ye,
  • songxia ke,
  • xiaohui sun,
  • jing qian,
  • ziqing zhou,
  • minhong lin,
  • baoying he,
  • renze shen
Zhanchao Ye
School of Stomatology, Fujian Medical University, Department of Stomatology, Zhongshan Hospital of Xiamen University
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songxia ke
School of Stomatology, Fujian Medical University, Department of Stomatology, Zhongshan Hospital of Xiamen University
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xiaohui sun
College of Chemical Engineering, Huaqiao University
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jing qian
College of Chemical Engineering, Huaqiao University,Department of laboratory, Putian Center for Disease Prevention and Control
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ziqing zhou
School of Stomatology, Fujian Medical University, Department of Stomatology, Zhongshan Hospital of Xiamen University
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minhong lin
School of Stomatology, Fujian Medical University, Department of Stomatology, Zhongshan Hospital of Xiamen Universit
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baoying he
Department of Oncology, Zhongshan Hospital of Xiamen University
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renze shen
School of Stomatology, Fujian Medical University, Department of Stomatology, Zhongshan Hospital of Xiamen University

Corresponding Author:[email protected]

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Abstract

In this work, double-layer heterogeneous calcium alginate scaffolds were designed for alveolar bone defects where the outer layer featured high hardness and slow degradation, and the inner layer characterized by large pores and rapid degradation. The morphology of the calcium alginate scaffold was akin to that of bone defects, and its direct implantation reduced the operation time. A higher concentration of calcium alginate resulted in smaller pores and slower degradation. Calcium alginate can promote the formation of mineralized nodules and the expression of genes related to mineralization without inducing cytotoxic effects. It also promoted the expression of cellular inflammatory factors, potentially through the TLR4 pathway. In vivo studies confirmed that calcium alginate did not promote the aggregation of inflammatory cells nor the expression of inflammatory factors. In conclusion, the scaffold's characteristics of high surface hardness and slow degradation were beneficial for surface osteogenesis and maintaining the defect's shape and osteogenic space. Conversely, rapid internal degradation favors the formation of bone tissue.
09 Oct 2024Submitted to Biotechnology Journal
12 Oct 2024Submission Checks Completed
12 Oct 2024Assigned to Editor
12 Oct 2024Review(s) Completed, Editorial Evaluation Pending
12 Oct 2024Reviewer(s) Assigned
31 Oct 2024Editorial Decision: Revise Major