Antiphospholipid syndrome (APS) is well known for its association with arterial and venous thrombosis. Intracardiac thrombosis -more often involving right atrium- although rare, could be a serious manifestation of the disease, complicating its course. We describe a 49-year-old man with known history of APS and multiple myocardial infarction episodes and episodes of venous and arterial thrombosis, who presented with worsening dyspnea. Further evaluations revealed the presence of a mobile mass in the right ventricular outflow tract (RVOT) in favor of thrombosis. The patient was medically managed with aggressive anticoagulation and the RVOT mass underwent regression on follow-up imaging investigations.