Stream networks are highly abundant across Earth’s surface, reflecting the tectonic and climatic history under which they have developed. Recent studies suggest that branching angles are strongly correlated with climatic aridity. However, the impact of tectonic forcing, especially in tectonically active regions, remains ambiguous. Here we analyze the branching angles of major stream networks on the eastern Tibetan Plateau, a region with complex tectonics, variable climate, and diverse landscapes. We find that spatial variations in tectonic uplift (as reflected in channel gradients) shape the branching geometry of stream networks on the steep eastern margin while in the flat interior of the eastern Tibetan Plateau, branching angles are mainly controlled by climatic aridity. This leads to the conclusion that, in the steep margin of the eastern Tibetan Plateau, climatic impacts on branching angles are overprinted by stronger tectonic controls.