Slow slip events (SSEs) are transient slow fault slips primarily occurring at plate boundaries and are sometimes linked to large earthquakes and earthquake swarms. In the Middle America subduction zone, SSEs have been observed primarily in Guerrero and Oaxaca, Mexico, and the Nicoya Peninsula, Costa Rica. The relationship between megathrust earthquakes and SSEs has been actively investigated in this subduction zone. However, much still remains unclear on the relationship between moderate earthquakes and SSEs. Clarifying this relationship is important for comprehending the mechanisms governing seismicity in this subduction zone. Here, we employed the spatiotemporal epidemic-type aftershock-sequence model to detect swarms of M 4.3 or larger earthquakes in the ANSS catalog from 2001 to 2024. We identified 59 earthquake swarm sequences and delineated three earthquake swarm concentration areas: in the vicinity of the Guerrero seismic gap, off the coast of Chiapas, Mexico, and around the Burica Peninsula at the Costa Rica–Panama border. To explore the potential link between earthquake swarms and SSEs, a comparative analysis was conducted between the earthquake swarms and previously documented SSEs. Additionally, global navigation satellite system data was analyzed to identify transient displacements potentially caused by previously unreported SSEs. The findings reveal that the 2002 and 2007 Guerrero and 2014 Nicoya Peninsula SSEs were accompanied or followed by earthquake swarms. Furthermore, transient crustal movements, possibly attributable to SSEs, coincided with earthquake swarms in Costa Rica, Panama, and Chiapas. The study offers new insights into the connection between seismicity and SSEs in the Middle America subduction zone.