Model projections of changes in precipitation express large uncertainties, partly owing to climate noise from internal variability dominating the greenhouse gas forced signal. In a high-resolution initial-condition regional climate model ensemble, we investigate this signal-to-noise problem for precipitation changes in major river basins in Western Europe, focusing on how it depends on different methods of spatial aggregation. This is motivated by the common need for spatially aggregated climate change information. We find that the forced climate signal is only moderately dependent on spatial aggregation. However, uncertainties (and likewise the signal-to-noise ratio) strongly depend on the aggregation method. Computing uncertainties at the grid scale – as typically provided in maps in climate change studies – and averaging those to larger areas, leads to large uncertainty estimates and corresponding low signal-to-noise ratios. This method does not account for spatiotemporal dependencies in the underlying data, and is representative for the uncertainties at a specific location. Computing changes at the grid scale, spatially averaging those per ensemble member, and computing the uncertainty in these spatial averages results in much smaller uncertainty estimates, up to a factor 2 for 1-day precipitation maxima in summer. This information is useful for stakeholders with an aggregated uncertainty perspective, e.g. insurance. Spatial aggregation of precipitation itself and computing uncertainties in basin-scale precipitation changes – relevant for e.g. river flooding – also yields smaller uncertainties, up to a factor 1.5 for 1-day summer maxima. This paper is intended to give guidance on processing uncertainty information depending on the application-specific needs.