As the clinical course of COVID-19 infection in SCD patients is not clear, close monitoring is essential. We emphasize that RBC exchange should be offered early to avoid possible deterioration. We present a case of COVID-19 infection in a SCD patient causing severe hemolysis, that improved after RBC exchange.

Soft tissue, bone, and teeth reconstruction is a challenge in patients with maxillary defects due to surgical resections. This article presents a 21-year-old male patient with a history of hemimaxillectomy . Secondary reconstruction was performed using buccal fat pad flap, free iliac crest bone graft, and dental implants

We suggest PLAID,APLAID and FCAS3 have to be considered as same diseases,because of our long-term clinical experiences and genetic results in six patients.Small proportion of CVID patients are also PLAID/APLAID/FCAS3 patients and all these have disease-causing-mutations in PLCG2-genes,so it may be better to define all of them as “PLCG2 deficiency”.

A 55-year-old man with left temporo-insulo-parietal glioblastoma was admitted because of abrupt excruciating pain in right arm and ipsilateral face. EEG showed a left central frontal rhythmic activity and complains were controlled with anti-epileptic drugs. Paroxysmal pain is an unusual manifestation of focal seizures and can be the only symptom.

Clinical Image

This case report describes the clinical history of a COVID-19 patient with a non-immediate diagnosis of severe dysphagia that required a gastrostomy positioning. A vocal folds paresis was observed for the first time in the course of a Sars-CoV-2 infection. Thanks to intensive rehabilitation treatment, the outcome was favourable.

A patient presenting with low back pain received 18 novel treatments of FDA approved low frequency sound wave stimulation known as Khan Kinetic Treatment (KKT). Following KKT he demonstrated improvement in pain, function, quality of life, sleep, and trunk range of motion with no adverse events.

In situation of a cat bite, although an external wound is small, prophylactic antibiotics should be used early and a closed observation is needed for sufficient periods. If symptoms continue, deep infection should be considered.

A patient with Birt-Hogg-Dubé Syndrome (BHDS) developed metastatic follicular thyroid cancer, which until now has never been described in someone with BHDS. Thyroid cancer is not currently recommended for screening with BHDS. This case presents implications for future guidelines and planning for renal transplant in patients with this condition.

A document by Aykut Aytulun. Click on the document to view its contents.

Behcet's disease is a systemic autoimmune disorder occasionally associated with otological manifestations, including sensorineural hearing loss. We are reporting a case of Behcet's disease, which was complicated by sensorineural hearing loss and managed successfully with anti-TNF agent Infliximab.

Imatinib is used as first-line treatment for chronic myeloid leukemia (CML) even in patients with impaired renal function. We successfully used therapeutic drug monitoring to determine the dose for re-administration of imatinib in a CML patient who initiated dialysis for acute renal dysfunction associated with the initial imatinib therapy.

Behcet’s disease (BD) is a vasculitis of unknown aetiology that is reported to accompany autoimmune diseases. We report a rare case of BD, Addison’s disease, Hashimoto’s disease, and subclinical coeliac disease all occurring in one patient which has not previously been reported.

Acute epibulbar infections are one of the most frequently diagnosed ophthalmologic infections. They are usually self-limiting but can lead to a viral preseptal cellulitis mimicking a severe bacterial infection. Early diagnosis is important to shorten the course of recovery.

Progressive familial intrahepatic cholestasis (PFIC) is an abnormality in the formation and secretion of bile components and bile acids.We present a case of a 6-years-old female with Type 3 of PFIC which was confirmed via detecting pathogenic variants in the ABCB4 gene.

Medullary thyroid carcinoma (MTC) typically manifests as a solitary thyroid nodule, and a miliary pattern on conventional chest imaging is not commonly observed. Here, we report a 58-year-old woman with constitutional symptoms, and innumerable small nodules on chest imaging, mimicking miliary tuberculosis. Pathologic findings confirmed a diagnosis of metastatic MTC.

Inguinal hernia can be present in the beam path of photon radiotherapy for prostate cancer. To avoid exposing the radiosensitive intestinal tract potentially included in hernia sacs, repair surgery prior to photon radiotherapy should be considered for hernia-positive prostate cancer patients.

Anil Nepali1,2, Satyam Kharga1, Malavika Jayan2,3, Prakriti Adhikari4, Amit Shah1, Vivek Sanker2,5