IntroductionHerpes simplex virus (HSV), is a member of an enveloped, double-stranded DNA virus family named Herpesviridae, this virus causes latent infection of neural ganglia(1). It has a worldwide distribution and a wide range of clinical presentations depending on the host’s immune status and the infection site. In immunocompetent individuals, the most common presentation includes painful vesicles and erosions on an erythematous base, which can evolve into pustules and/or ulcerations (2, 3). In immunocompromised individuals such as solid organ or bone marrow transplant recipients, patients with hematologic malignancies, and acquired immunodeficiency syndrome (AIDS), HSV infection can have atypical manifestations, including chronic non-healing ulcers, verrucous plaques, and large protruding tumors. In the case of immunosuppressed patients, the lesions may disseminate and occur at multiple sites, including atypical locations such as the buttocks, abdomen, and lower back. Depending on the level of immunosuppression, HSV infection can have a variable duration, severity, and outcome. It can affect multiple or atypical sites, such as the abdominal, and thoracic regions, or even become disseminated(4, 5). In this article, we report a case of cutaneous perianal infection that presented as warty skin-colored papules and plaques underline the challenges in the morphologic and clinical diagnosis of this entity, and review the literature on verrucous HSV lesions in non-HIV patients.