In the field of physiological signals monitoring and its applications, non-contact technology is often proposed as a possible alternative to traditional contact devices. The ability to extract information about a patient’s health status in an unobtrusive way, without stressing the subject and without the need of qualified personnel, fuels research in this growing field. Among the various methodologies, RADAR-based non-contact technology is gaining great interest. This scoping review aims to summarize the main research lines concerning RADAR-based physiological sensing and machine learning applications reporting recent trends, issues and gaps with the scientific literature, best methodological practices, employed standards to be followed, challenges, and future directions. After a systematic search and screening, one hundred and ninety two papers were collected following the guidelines of PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses). The included records covered two macro-areas being regression of physiological signals or physiological features (n = 68 papers) and the other a cluster of papers regarding the processing of RADAR-based physiological signals and features applied to four fields of interest, being RADAR-based diagnosis (n = 73), RADAR-based human behaviour monitoring (n = 21), RADAR-based biometrics authentication (n = 18) and RADAR-based affective computing (n = 9). Papers collected under the diagnosis category were further divided, on the basis of their aims: in breath pattern classification (n = 39), infection detection (n = 10), sleep stage classification (n = 9), heart disease detection (n = 8) and quality detection (n = 7). Papers collected under the human behaviour monitoring were further divided based on their aims: fatigue detection (n = 8), human detection (n = 7), human localisation (n = 4), human orientation (n = 2), and activities classification (n = 3).