Maintaining efficiency, lowering operating expenses, and satisfying growing customer needs all depend on the optimization of logistics within worldwide supply chains. Traditional logistics management systems are proving inadequate as global supply chains get increasingly complicated from events including changing demand, geopolitical disturbances, and legislative differences. With an eye on demand forecasting, route optimization, and inventory management, this work explores how machine learning (ML) technology might be used to maximize logistics processes. A subset of artificial intelligence (AI), machine learning provides sophisticated features for pattern recognition, huge dataset analysis, and real-time decision-making enablement. Logistics can be much improved by means of supervised learning methods for demand forecasting, reinforcement learning for dynamic route optimization, and unsupervised learning for inventory clustering. Moreover, predictive analytics is investigated for its ability to reduce risks by projecting supply chain disturbances depending on outside variables including political events, climate change, and industry trends. The approach used in this study consists in a survey of current literature on machine learning applications in logistics as well as case studies of actual implementations by multinational companies like Amazon and DHL. These case studies show how greatly cost reductions, lower delivery times, and enhanced operational efficiency resulting from machine learning-driven logistics systems have resulted. By constantly changing paths depending on traffic and environmental circumstances, machine learning algorithms used to route optimization have enabled speedier delivery and reduced fuel usage. Machine learning models have exceeded conventional statistical approaches in demand forecasting, therefore enabling improved inventory control and a decrease in stockouts and overstocks. The report also emphasizes the difficulties of application even as the benefits of adding machine learning into logistics are obvious. Widespread adoption is seriously hampered by issues including data protection, the integration of machine learning algorithms with older systems, and the need of specialized knowledge. Still, machine learning appeals as a solution for enhancing worldwide supply chain logistics because of possible cost savings, higher efficiency, and improved customer service. This paper ends with recommendations for next research prospects in the evolution of increasingly sophisticated machine learning techniques fit for the increasing complexity of worldwide supply networks. Furthermore open for investigation are the ethical ramifications of machine learning in logistics, especially with relation to automated decision-making and data protection. Machine learning will become ever more important in driving innovation and optimization in logistics as supply networks change.