Various age-related neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), Alzheimer’s, Huntington’s, and Parkinson’s, are associated with the same basic disorder: the loss of nerve cells capacity to fold their proteins correctly, which causes protein aggregations that form "clumps" that end up generating the cell death (Figure 1). To better understand protein folding let's visualize folded proteins as a folded paper plane when both have a correct 3D conformation they can accomplish their respective functions, catalyze a reaction, in the case of some proteins or fly in the case of the plane. Incorrect folding cause that proteins lose their normal functions and cause protein aggregations that form "clumps" that end up generating the cell death. Analogously, a paper plane incorrectly folded would not be able to fly and would form a paper ball with other defective paper planes. With this example is easier to understand the conformation or shapes that some proteins acquire (Figure 1).