In this investigation, we introduce new definitions of (p,q)-derivative and integral and discuss their fundamental properties. Some new Hermite-Hadamard inequalities employing newly defined (p,q)-integral are also obtained for convex functions. Furthermore, we are interested in finding (p,q)-estimates for midpoint and trapezoidal type inequalities for differentiable functions. It is revealed that the inequalities given in this article are extensions of offered inequalities in the literature of Hermite-Hadamard inequalities.