Essential Site Maintenance: Authorea-powered sites will be updated circa 15:00-17:00 Eastern on Tuesday 5 November.
There should be no interruption to normal services, but please contact us at [email protected] in case you face any issues.

loading page

Nationwide population-based cohort study of adverse obstetric outcomes in pregnancies with myoma or following myomectomy: Retrospective cohort study
  • +8
  • Se Jin Lee,
  • Hyun-Sun Ko,
  • Sunghun Na,
  • Jin Young Bae,
  • Won Joon Seong,
  • Jong Woon Kim,
  • Jaeeun Shin,
  • Hae Joong Cho,
  • Gyu Yeon Choi,
  • Geum Joon Cho,
  • In Yang Park
Se Jin Lee
Kangwon National University Hospital

Corresponding Author:[email protected]

Author Profile
Hyun-Sun Ko
Catholic University of Korea College of Medicine
Author Profile
Sunghun Na
Kangwon National University Hospital
Author Profile
Jin Young Bae
Catholic University of Daegu
Author Profile
Won Joon Seong
Kyungpook National University School of Medicine
Author Profile
Jong Woon Kim
Chonnam National University Medical School
Author Profile
Jaeeun Shin
Catholic University of Korea College of Medicine
Author Profile
Hae Joong Cho
Wonkwang University Hospital
Author Profile
Gyu Yeon Choi
Soonchunhyang University Hospital Seoul
Author Profile
Geum Joon Cho
Korea University College of Medicine and School of Medicine
Author Profile
In Yang Park
Catholic University of Korea College of Medicine
Author Profile

Abstract

Objectives: To evaluate risks of adverse obstetric outcomes in pregnancies with myoma(s) or in pregnancies following myomectomy. Design: Retrospective cohort Setting: The national health insurance database Population: Women who had delivered in Republic of Korea, between 2004 and 2015 Methods: We analyzed the risks of adverse pregnancy outcomes in pregnancies with myoma(s) or in pregnancies following myomectomy, compared to those in women without a diagnosed myoma. Multivariate logistic regression analysis was performed. Main Outcome Measures: The adverse obstetric outcomes. Results: There are 740,675 women who had never been diagnosed with myoma (Group A), 38,402 women who had diagnosed myoma(s) but no history of myomectomy (Group B), and 9,890 women who had a history of myomectomy (Group C). Group B and Group C had significantly higher risks of cesarean section and placenta previa, compared to Group A. The risks of uterine rupture, preterm birth, and low birth weight were significantly higher in Group C (aOR 12.78, 95% CI 6.5-25.13, p < 0.001; aOR 1.64, 95% CI 1.47-1.84, p < 0.001; and aOR 1.53, 95% CI 1.39-1.68, p < 0.001, respectively), but not in Group B, compared to Group A. The incidence of uterine rupture was the highest at delivery within one year after myomectomy and decreased over time after myomectomy. Conclusions: When a woman who might become pregnant later on is diagnosed with uterine myoma, she should be counseled about the risk of myoma(s) and myomectomy on obstetric complications, especially including the significant risk of uterine rupture in pregnancies following myomectomy.