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Evaluation of the SIMULRESP: a simulation software of child and teenager cardiorespiratory physiology
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  • David Brossier,
  • Olivier Flechelles,
  • Michael Sauthier,
  • Catherine Engert,
  • Youssef Chahir,
  • Guillaume Emeriaud,
  • Farida Cheriet,
  • Philippe Jouvet,
  • Simon de Montigny
David Brossier
Centre Hospitalier Universitaire Sainte-Justine Centre de Recherche

Corresponding Author:[email protected]

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Olivier Flechelles
Centre Hospitalier Universitaire de Martinique
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Michael Sauthier
Centre Hospitalier Universitaire Sainte-Justine Centre de Recherche
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Catherine Engert
Centre Hospitalier Universitaire Sainte-Justine Centre de Recherche
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Youssef Chahir
Groupe de Recherche en Informatique Image Automatique et Instrumentation de Caen
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Guillaume Emeriaud
Centre Hospitalier Universitaire Sainte-Justine Centre de Recherche
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Farida Cheriet
Centre Hospitalier Universitaire Sainte-Justine Centre de Recherche
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Philippe Jouvet
Centre Hospitalier Universitaire Sainte-Justine Centre de Recherche
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Simon de Montigny
Centre Hospitalier Universitaire Sainte-Justine Centre de Recherche
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Abstract

BACKGROUND: Mathematical models based on the physiology when programmed as a software can be used to teach cardiorespiratory physiology and to forecast the effect of various ventilatory support strategies. We developed a cardiorespiratory simulator for children called “SimulResp”. The purpose of this study was to evaluate the quality of SimulResp. METHODS: SimulResp quality was evaluated on accuracy, robustness, repeatability and reproducibility. Blood gas values (pH, PaCO 2, PaO 2 and SaO 2) were simulated for several subjects with different characteristics and in different situations and compared to expected values available as reference. The correlation between reference and simulated data was evaluated by the coefficient of determination and Intraclass correlation coefficient. The agreement was evaluated with the Bland & Altman analysis. RESULTS: SimulResp produced healthy child physiological values within normal range (pH 7.40 +/- 0.5; PaCO2 40 +/- 5 mmHg, PaO2 90 +/- 10 mmHg; SaO2 97% +/- 3%) starting from a weight of 25 to 35 kg, regardless of ventilator support. SimulResp failed to simulate accurate values for subjects under 25 kg and/or affected with pulmonary disease and mechanically ventilated. Based on the repeatability was considered as excellent and the reproducibility as mild to good. SimulResp’s prediction remains stable within time. CONCLUSIONS: The cardiorespiratory simulator SimulResp requires further development before future integration into a clinical decision support system.
10 May 2022Submitted to Pediatric Pulmonology
10 May 2022Submission Checks Completed
10 May 2022Assigned to Editor
01 Jun 2022Reviewer(s) Assigned
04 Jul 2022Review(s) Completed, Editorial Evaluation Pending
23 Jul 2022Editorial Decision: Revise Minor
11 Oct 20221st Revision Received
11 Oct 2022Assigned to Editor
11 Oct 2022Submission Checks Completed
11 Oct 2022Reviewer(s) Assigned
18 Nov 2022Review(s) Completed, Editorial Evaluation Pending
23 Nov 2022Editorial Decision: Revise Minor
21 Dec 20222nd Revision Received
21 Dec 2022Submission Checks Completed
21 Dec 2022Assigned to Editor
21 Dec 2022Review(s) Completed, Editorial Evaluation Pending
21 Dec 2022Reviewer(s) Assigned
30 Jun 2023Editorial Decision: Accept