Atlantic DIP: Is weight gain less than that recommended by IOM safe in
obese women with Gestational Diabetes Mellitus? – a retrospective study
Abstract
Objective The study objective was to examine maternal and infant
outcomes for obese GDM women who lost weight or gained 0-5 kg during
pregnancy. Design A 7-year retrospective study of pregnancy outcomes for
obese GDM women. Setting The ATLANTIC DIP consists of 5 antenatal
centres along the Irish Atlantic seaboard. Population A total of 754
women met the inclusion criteria. Methods Women were stratified into 3
distinct groups according to their weight gain status: lost weight or
gained less than 5 kg (Group 1, n=237 (31.4%)), gained 5-9kg (Group 2,
n=77 (10.2%)) or gained >9kg (Group 3 n=440 (58.4%)). The
groups were further subdivided according to treatment modality: diet
alone (GDM-D) or diet and insulin (GDM-I). Main outcome measures
Maternal (eg.preeclampsia, pregnancy induced hypertension (PIH)) and
infant outcomes (eg.mortality, prematurity, macrosomia, large for
gestational age (LGA)) were assessed. Results Women in Group 1 were
older with a higher booking BMI compared to Groups 2 and 3. Logistic
regression analysis adjusted for baseline BMI, insulin use, smoking
status, parity, family history, ethnicity and age determined no
significant difference in maternal or infant outcomes for women in
Group1 compared to those in Group 2. Women with excessive weight gain
had higher rates of PIH, macrosomia and LGA. Conclusion In our
population, weight gain less than IOM guideline does not appear to be
associated with adverse outcomes. However, further validation through a
prospective study with a larger obese GDM cohort is required before
these findings could be recommended for routine clinical use.