The first cases of patients infected with SARS-Cov-2 virus were recorded in China in November 2019, and then rapidly spread to all countries around the world, causing a global pandemic. Much is known about the pathophysiology of this virus infection, but perhaps not enough. One of the aspects still to be investigated is the correlation between the renin-angiotensin system (RAS) and SARS-Cov-2 infection. RAS is a physiological system with a key role in regulating the different functions of the human body. SARS-CoV-2, uses the enzyme ACE-2 as a potential factor of cell penetration and infectivity, moreover in the different stages of infection a functional variation of the RAS system has been noted in different targets and at different times. In particular, in this article, we discuss the role of RAS on SARS-Cov-2 infection, and possible therapies that acting modifiers the system.