The aim of this study was to define the correlation between visual qualitative method and semi-quantitative method for the study of the extension of myocardial edema by CMR in patients with Takotsubo syndrome (TTS). We analyzed 22 consecutive patients with a diagnosis of typical apical TTS. A total of 374 myocardial segments were analyzed. A high correlation between visual method and the semi-quantitative method of the T2 SI ratio (Pearson’s r = 0.82, p <0.001) was found. In the clinical setting the visual method provides a valid and reliable quantification of myocardial edema extension in patients with TTS.