Abstract
Background &objectives:The present study was to carry out 90 days
repeated oral toxicity of Urai mathirai in wistar albino rats.
Methods:The chronic toxicity study was carried out as per (OECD) test
guideline 408 and Central Council for Research in Ayurvedic Sciences
(CCRAS) respectively. In this study, theUrai mathirai drug solution was
administered at dose of (10, 50 and 100mg/kg b.wt) for every 24 hours
orally upto 90 days for all the three groups. At the end of each study,
hematological and biochemical analysis were evaluated. Histopathological
examination of vital organs of the rats were taken for gross findings,
compared to controls. Distilled water aided as a control in all the
tests. Results: There was no significant difference (p >
0.05) observed in the relative organs weight, body weight,
hematological, biochemical parameters, and gross abnormalities when
compared to the control. No mortality was recorded with respect drug
effect. Interpretation&conclusions: The results may lead that the oral
administration of the Urai mathiraiat doses of 10, 50 and100
mg/kg.b.wtdoes not showedany toxicity effect in wistar rats during the
experimental period. Keywords: Urai mathirai; chronic toxicity; herbal
formulation; histopathology.