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Bronchopulmonary dysplasia: incidence and severity in premature infants born at high altitude.
  • Jefferson Buendia,
  • Cristian Ramieez,
  • Dione Benjumea
Jefferson Buendia
University of Antioquia

Corresponding Author:[email protected]

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Cristian Ramieez
UNIREMINGTON Facultad de Ciencias de la Salud
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Dione Benjumea
UNIREMINGTON Facultad de Ciencias de la Salud
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Abstract

Background: Bronchopulmonary dysplasia (BPD) is the most common cause of chronic lung disease in children born prematurely. There is little information about the epidemiology and severity of BPD places with high altitude. This study aimed to evaluate the frequency of BPD severity levels and the associated risk factors with severity in a cohort of preterm newborns ≤34 weeks of gestational age born in Rionegro, Colombia Materials and methods: We carried out a retrospective analytical cohort of preterm newborns without major malformations from Rionegro, Colombia between 2011-2018 admitted to neonatal intensive unit at high altitude (2200m above sea level). The main outcomes were the incidence and severity of bronchopulmonary dysplasia. Results: The bronchopulmonary dysplasia incidence was 25.7% (95% CI, 21.6-29.9). Bronchopulmonary dysplasia was moderate in 62.1% of patients and severe in 26.7%. After modeling regression analysis, the final variables associated with BPD severity levels were: sepsis (OR 2.37 CI 95% 1.04-5.40) and pulmonary hypertension (OR 3.79 CI95% 1.19-12). Conclusion: The incidence of BPD was higher and similar to cities with higher altitudes. In our population, the variables associated with BPD severity levels were: duration of oxygen therapy and pulmonary hypertension. It is necessary to increase the awareness of risk factors, the effect of clinical practices, and early recognition of bronchopulmonary dysplasia to reduce morbidity in patients with this pathology.
15 Sep 2021Submitted to Pediatric Pulmonology
16 Sep 2021Submission Checks Completed
16 Sep 2021Assigned to Editor
20 Sep 2021Reviewer(s) Assigned
07 Oct 2021Review(s) Completed, Editorial Evaluation Pending
07 Oct 2021Editorial Decision: Revise Major
25 Oct 20211st Revision Received
26 Oct 2021Submission Checks Completed
26 Oct 2021Assigned to Editor
26 Oct 2021Reviewer(s) Assigned
09 Nov 2021Review(s) Completed, Editorial Evaluation Pending
09 Nov 2021Editorial Decision: Revise Minor
10 Nov 20212nd Revision Received
12 Nov 2021Submission Checks Completed
12 Nov 2021Assigned to Editor
12 Nov 2021Reviewer(s) Assigned
12 Nov 2021Review(s) Completed, Editorial Evaluation Pending
12 Nov 2021Editorial Decision: Accept
30 Nov 2021Published in Pediatric Pulmonology. 10.1002/ppul.25763