The aim of this meta-analysis is to investigate the effectiveness of chloroquine in treating coronavirus, in general not only novel coronavirus (COVID¬-19), by pooling the results of randomized controlled clinical trials (RCTs). Only 28 publications were identified; none of which was a RCT. Identified studies were published between 1987 and March 15, 2020. Of these 28 publications, 7 were published in 2020 and discussed the effectiveness of chloroquine against COVID-19. In conclusion, this meta-analysis could not prove that chloroquine is an effective treatment against coronavirus in general or COVID-19 in particular. Expanded access trials should be encouraged especially that chloroquine is available, cheap and relatively safe drug.