Cardiac resynchronization therapy with His-bundle pacing (His-CRT) is evolving rapidly as a viable cardiac device strategy for the treatment of severe chronic heart failure. The success of this technique in patients with congenital heart disease is facilitated by advanced integrated imaging modalities. We report a case of His-CRT pacing for the management of a patient with heart failure with severely reduced ejection fraction, left bundle branch block and congenital heart disease characterized by Scimitar syndrome with cardiac dextroposition. We highlight the contribution of integrated imaging modalities to guide accurate lead positioning.