Role of nanostructures in allergy: adverse effects, diagnostics, and
treatment
- Cristobalina Mayorga,
- Ezequiel Perez-Inestrosa,
- Javier Rojo,
- Marta Ferrer,
- Maria Isabel Montañez
Javier Rojo
Instituto de Investigaciones Químicas (IIQ), CSIC - Universidad de Sevilla
Author ProfileMaria Isabel Montañez
IBIMA-Regional University Hospital of Málaga
Author ProfileAbstract
Nanotechnology is science, engineering, and technology conducted at the
nanoscale, which is about 1 to 100 nanometers. It has led to the
development of nanomaterials, which behave very differently compared
with materials with larger scales and can be applied in a wide range of
applications in biomedicine. The physical and chemical properties of
materials of such small compounds depend mainly on the size, shape,
composition, and functionalisation of the system. Nanoparticles, carbon
nanotubes, liposomes, polymers, dendrimers, nanogels, among others, can
be nanoengineeried for controlling all parameters, including their
functionalisation with ligands, which provide the desired interaction
with the immunological system. However, undesired issues related to
their toxicity and hypersensitivity responses have impeded more rapid
health applications. Through interactions with the immune system, some
of these nanostructures show promising applications as vaccines and
diagnostics tools. Dendrimeric Antigens, Nanoallergens, and
nanoparticles are potential tools for the in vitro diagnosis of allergic
reactions. Glycodendrimers, liposomes, polymers, and nanoparticles have
shown interesting applications in immunotherapy. There are wide panels
of structures accessible, and controlling their physico-chemical
properties would allow the obtainment of safer and more efficient
compounds for clinical applications goals, either in diagnosis or
treatment.01 Jul 2020Submitted to Allergy 02 Jul 2020Submission Checks Completed
02 Jul 2020Assigned to Editor
04 Jul 2020Reviewer(s) Assigned
19 Jul 2020Review(s) Completed, Editorial Evaluation Pending
21 Jul 2020Editorial Decision: Revise Minor
09 Oct 20201st Revision Received
14 Oct 2020Submission Checks Completed
14 Oct 2020Assigned to Editor
16 Oct 2020Reviewer(s) Assigned
25 Oct 2020Review(s) Completed, Editorial Evaluation Pending
28 Oct 2020Editorial Decision: Revise Minor
30 Nov 20202nd Revision Received
01 Dec 2020Submission Checks Completed
01 Dec 2020Assigned to Editor
02 Dec 2020Reviewer(s) Assigned
13 Dec 2020Review(s) Completed, Editorial Evaluation Pending
23 Dec 2020Editorial Decision: Revise Minor
13 Jan 20213rd Revision Received
13 Jan 2021Submission Checks Completed
13 Jan 2021Assigned to Editor
15 Jan 2021Reviewer(s) Assigned
19 Jan 2021Review(s) Completed, Editorial Evaluation Pending
19 Jan 2021Editorial Decision: Revise Minor
27 Jan 20214th Revision Received
28 Jan 2021Submission Checks Completed
28 Jan 2021Assigned to Editor
29 Jan 2021Review(s) Completed, Editorial Evaluation Pending
31 Jan 2021Editorial Decision: Accept