Many articles have reported that cancer patients are more susceptible to COVID-19 pneumonia and cancer patients with COVID-19 seem to be more often tend to develop severe events. In these studies of infected cancer patients, factors associated with a higher risk of developing severe events included age, baseline fragility, and anti-tumor treatment. However, specific reasons regarding why infected patients with cancer have a higher probability of severe events compared to non-cancer infected patients remain unclear. Thus, we sought to study one particular factor to determine a potential associative effect: differences in Computed tomography (CT) findings. In our study,we found that cancer patients represent a special population which multiple lobes of the lungs were more susceptible to infection by the SARS-CoV-2, and thus were more likely to be transferred from mild illness to severe, should be deserved more intensive attention during the SARS-CoV-2 pandemic.