In this paper, we consider the Cauchy problem for three-dimensional isentropic compressible radiation hydrodynamic equations with density-dependent viscosity coefficients. When the viscosity coefficients are given as power of density ($\rho^\delta$ with $\delta>1$), we establish the local-in-time existence of classical solutions containing a vacuum for large initial data. Here, we point out that the initial layer compatibility conditions are not necessary.