Abstract
Cholera is an ancient and widespread infectious disease, mainly
manifested as severe vomiting, diarrhea, water loss, and high mortality.
It belongs to the group of international quarantine infectious diseases,
and Vibrio cholerae is the pathogen of human cholera. Since 1817,
there have been seven global cholera pandemics, which have caused
hundreds of millions of human deaths. The cause of these cholera
epidemics is highly complex; how it spreads globally and the reason for
seasonal epidemic peaks in epidemic areas remains unclear. Most sporadic
outbreaks of cholera are related to aquatic products or related water
bodies.