Discussion about clinical value of detection of IL-10, IL-1β, IL-6,
MCP-1, TNF-α, IP-10 and IL-4 for the diagnosis of COVID-19
Abstract
Objective: Analyse the relationship between COVID-19 with IL-10, IL-1β,
IL-6, MCP-1, TNF-α, IP-10 and IL-4. Methods: The serum levels of
cytokines above were detected by ELISA. Results: Most of the serum level
of cytokines above in patients with COVID-19 were significantly higher
than those in healthy people, and some of them were significantly higher
than those in patients with other diseases. AUC of COVID-19 diagnosed by
they were 0.735, 0.775, 0.595, 0.821, 0.848, 0.387 and 0.987. The serum
levels of some cytokines in male patients had noticeably higher than
those in female patients. The serum level of almost all cytokines of the
elderly was higher than that of the youth and middle-aged patients. The
serum level of IP-10 in patients with COVID-19 was positively correlated
with IgM, while TNF-α was negatively correlated with IgG. The levels of
cytokines in patients were higher at 25 days after onset than at 20
days, TNF-α and IL-4 were significantly lower at 30 days than at 25
days, while IP-10 were reversed. Conclusion: The detection of cytokines
have some clinical value for diagnosis of COVID-19, and that of IL-4 and
TNF-α was the best. The levels of cytokines in patients have some
relationships with gender, age and course of disease.