Hematopoietic Stem Cell Transplant (HSCT) is increasingly being used as a curative treatment for various malignant and non-malignant conditions. Second malignancies are known long term complication post HSCT. Myeloid malignancies rarely occur post allogenic HSCT. To the best of our knowledge there are no reported case of myeloid malignancy occurring in sickle cell disease (SCD) patient post haploidentical HSCT. We report 2 patients with SCD, who developed Acute Myeloid Leukemia (AML) with monosomy 7 post HSCT. Long-term follow-up is needed post allogenic HSCT even if done for benign conditions like SCD with no prior chemotherapy or malignancy history.