Ultrasound performed right after birth can predict the respiratory
support need of neonates----A diagnostic accuracy study
Abstract
Background Lung ultrasound (LUS) is widely used to diagnose neonatal
respiratory diseases. However, to our knowledge, few straightforward
method was reported to predict respiratory support need precisely. Our
aim is to determine the diagnostic accuracy of a semiquantitative LUS
assessent method predicting the need for respiratory support.
Methods We conducted a prospective diagnostic accuracy study following
STARD (Standards for the Reporting of Diagnostic Accuracy Studies)
guidelines at a tertiary level academic hospital between 2019 to 2020.
310 late preterm and term infants enrolled. They were delivered in the
obstetric department and transferred to a monitoring room to determine
whether they need NICU treatment. The LUS assessment was performed for
each participant at one of following timings–0.5h, 1h, 2h, 4h, 6h after
birth. Reliability was tested by ROC analysis. Surfactant administration
and other respiratory support were based on 2019 European guidelines as
well as their clinical condition. Results 74 were confirmed to need
respiratory support and 236 were healthy according to a 3-day follow up.
Six LUS image patterns can be seen in these infants right after birth.
Two “high-risk” patterns well relate to respiratory support need(area
under the curve(AUC) = 0.95; 95% CI, 0.92-0.98, p<0.001).
This reliability can be supported by AUC of “low-risk” patterns(AUC =
0.89, 95%CI, 0.85-0.93, p<0.001). Predictive value of LUS is
much greater than that of using respiratory symptoms(e.g.respiratory
rate)(AUC of LUS vs AUC of respiratory rate, p<0.01).
Conclusions LUS can predict respiratory support need and is more
reliable than the assessment based on respiratory symptoms.