Ibuprofen (IBU) is a non-steroidal anti-inflammatory drug (NSAID). A clinician wishing to avoid opioid pain control may consider a combination of orally administered ibuprofen (IBU) and acetaminophen for pain control. In dentistry, it is commonly recommended to take oral IBU 400-800mg and acetaminophen 325-1000 mg to control postoperative pain following third molar extraction(s). This combination can avoid the use of a narcotic prescription for pain control. However, many patients are taking anticoagulants for a variety of medical conditions and are told not to take IBU fearing an additive effect of IBU with the anticoagulant. This mini-review paper addresses the anticoagulant effects of IBU when administered as a single agent and the interactions with orally administered anticoagulant, antiplatelet, or antithrombotic agents.