Abstract
The first SARS-CoV-2 pandemic has affected most countries causing
hundreds of thousands of deaths. Evolution of the pandemic may involve
endemicity with or without significant secondary waves. We observed that
disease severity (p=0.006) and duration of symptoms (p<0.001)
declined over time in an isolated rural community. This decline was not
driven by changes in patient age structure nor by changes in temperature
or precipitations. The underlying mechanism may be relevant for COVID-19
management.