Polycystic ovarian syndrome and risk of breast, endometrial, and ovarian
cancer: a systemic review and meta-analysis
Abstract
Background: Polycystic ovarian syndrome (PCOS) is one of the most common
endocrine disease affecting the reproductive age women. Objective: To
investigate the relationship between PCOS and breast, ovarian, and
endometrial cancer. Search Strategy: Systematic search of PubMed, EMBASE
using keywords ‘PCOS’, ‘ovarian cancer’, ‘breast cancer’ and
‘endometrial cancer’. Selection Criteria: The study providing the
relative risk (RR) in the cohort study, odds risk(OR) in the
case-control study, and 95%confidence interval (95%CI) were included.
The single-case report and the non-English study were excluded. Data
Collection and Analysis: This meta-analysis was performed by calculating
RR, OR and 95%CI using random-effect models. Main Result: A total of 21
studies (8 cohort studies,13 case-control studies) involving 3831083
participants fulfilled the inclusion criteria. Based on the results of
cohort studies and case-control studies, the prevalence of breast cancer
among PCOS and non-PCOS women was not significant increased, the RR and
OR were 0.959 (95%CI, 0.806-1.112) and 0.991 (95%CI, 0.626-1.35),
respectively. Evidence from case-control studies showed that PCOS did
not increase the risk of endometrial and ovarian cancer, the summary ORs
of case-control studies were 1.288 (95%CI,0.763-1.814) and 1.219
(95%CI, 0.816-1.623). The risk of endometrial and ovarian cancer was
significantly increased based on cohort studies, the overall RRs of
cohort studies were 2.542 (95%CI, 1.755-3.328) and 1.818 (95%CI,
1.222-2.414). Conclusion: The meta-analysis demonstrate that PCOS will
not increase the risk of breast cancer. Evidence from the cohort studies
suggests that PCOS significantly increases the risk of endometrial and
ovarian cancer, although the case-control studies did not.