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in NS
  • +14
  • Stefania Arasi,
  • Ilenia Panasiti,
  • Lucia Caminiti,
  • Mariaelisabetta Conte,
  • Sveva Castelli,
  • Nonhlanhla Lunjani,
  • Paola Martelli,
  • Giovanni Pajno,
  • SImone Pelosi,
  • Ekaterina Potapova,
  • Ifigenia Sfika,
  • Ge Tan,
  • Salvatore Tripodi,
  • Danilo Villalta,
  • Valeria Villella,
  • Paolo Matricardi,
  • Cezmi Akdis
Stefania Arasi
Ospedale Pediatrico Bambino Gesu

Corresponding Author:[email protected]

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Ilenia Panasiti
Universitat Zurich Schweizerisches Institut fur Allergie- und Asthmaforschung
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Lucia Caminiti
Universita degli Studi di Messina Dipartimento di Medicina Clinica e Sperimentale
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Mariaelisabetta Conte
Ospedale Santa Maria degli Angeli di Pordenone
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Sveva Castelli
Charite Universitatsmedizin Berlin Institut fur Medizinische Immunologie
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Nonhlanhla Lunjani
Universitat Zurich Schweizerisches Institut fur Allergie- und Asthmaforschung
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Paola Martelli
Ospedale Santa Maria degli Angeli di Pordenone
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Giovanni Pajno
Universita degli Studi di Messina Dipartimento di Medicina Clinica e Sperimentale
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SImone Pelosi
TPS Production Rome Italy
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Ekaterina Potapova
Charite Universitatsmedizin Berlin Institut fur Medizinische Immunologie
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Ifigenia Sfika
Ospedale Sandro Pertini
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Ge Tan
Universitat Zurich Schweizerisches Institut fur Allergie- und Asthmaforschung
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Salvatore Tripodi
Ospedale Sandro Pertini
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Danilo Villalta
Ospedale Santa Maria degli Angeli di Pordenone
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Valeria Villella
Ospedale Sandro Pertini
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Paolo Matricardi
Charite Universitatsmedizin Berlin Institut fur Medizinische Immunologie
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Cezmi Akdis
Universitat Zurich Schweizerisches Institut fur Allergie- und Asthmaforschung
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Abstract

BACKGROUND: Characterization of disease endotypes will open a new window for the treatment of allergic rhinitis (AR). Herein we provide the first attempt to identify specific AR phenotypes/endotypes and/or any biomarker/predictor for specific treatment response based on local biological parameters. METHODS: This observational study was carried out in 142 patients with seasonal AR and 20 non-allergic controls. Total IgE levels, specific IgE to 112 allergenic molecules and 92 proinflammatory and immunologic proteins were measured in both serum and nasal secretions (NS). RESULTS: We found increased values of MCPs and MMPs in adults both in NS and serum when compared with pediatric patients (p<.05). MCPs and MMPs might represent two effective predictors of chronic inflammation. CXCL9, CXCL10, CXCL11, MCPs and MMP1 showed an upward trend both in serum and NS for patients with ≥ 3 comorbidities vs non-allergic controls(p<.05). These data suggest the involvement of these chemokines in the late phase of chronic allergic inflammation in the nose. Serum levels of IL-6, IL-8 and IL-10 (p<.05) were significantly higher in patients with AR+asthma compared to patients with different comorbidities. Conversely, serum levels of neurotrophin-3 values (p<.05) were significantly higher in those with AR+eczema vs other comorbidities groups. A subgroup of patients with a nasal hypersecretory state,called “hypersecreter endotype” was characterized by paediatric age, male gender, grass pollen sensitization and distributed among persistent, mild or moderate to severe cases of AR. CONCLUSIONS: Our study sets the groundwork for an AR endotypization at molecular level, which is highly desirable to deliver a patient-tailored approach.