Abstract
We describe a case of Drug Reaction with Eosinophilia and Systemic
Symptoms (DRESS) to multiple CFTR modulators and piperacillin in an 8
year old female with CF. To our knowledge this is the first reported
case of delayed type, T-cell mediated hypersensitivity to multiple CFTR
modulators described in literature. Our findings suggest possible
cross-reactivity between CFTR modulators or multiple sensitisations,
which should be taken into account in similar cases.