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T CELL-MEDIATED HYPERSENSITIVITY TO LUMACAFTOR AND IVACAFTOR IN CYSTIC FIBROSIS
  • +5
  • Aida Semic-Jusufagic,
  • Monday Ogese,
  • Christopher Edwards,
  • Mark Wilkinson,
  • Claire Nissenbaum,
  • Tim Lee,
  • Pirmohamed Munir,
  • Dean Naisbitt
Aida Semic-Jusufagic
Leeds Teaching Hospitals NHS Trust

Corresponding Author:[email protected]

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Monday Ogese
University of Liverpool
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Christopher Edwards
Leeds Teaching Hospitals NHS Trust
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Mark Wilkinson
Leeds Teaching Hospitals NHS Trust
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Claire Nissenbaum
Leeds Teaching Hospitals NHS Trust
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Tim Lee
Leeds Teaching Hospitals NHS Trust
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Pirmohamed Munir
University of Liverpool
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Dean Naisbitt
University of Liverpool
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Abstract

We describe a case of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) to multiple CFTR modulators and piperacillin in an 8 year old female with CF. To our knowledge this is the first reported case of delayed type, T-cell mediated hypersensitivity to multiple CFTR modulators described in literature. Our findings suggest possible cross-reactivity between CFTR modulators or multiple sensitisations, which should be taken into account in similar cases.
03 Mar 2022Submitted to Pediatric Allergy and Immunology
08 Mar 2022Reviewer(s) Assigned
26 Mar 2022Review(s) Completed, Editorial Evaluation Pending
28 Mar 2022Editorial Decision: Revise Minor
06 May 20221st Revision Received
06 May 2022Review(s) Completed, Editorial Evaluation Pending
07 May 2022Reviewer(s) Assigned
25 May 2022Editorial Decision: Accept
Jun 2022Published in Pediatric Allergy and Immunology volume 33 issue 6. 10.1111/pai.13815