Antiplatelet therapy for transient ischaemic attacks and acute minor
strokes: current best practice and future
Abstract
In patients presenting with transient ischaemic attack and acute minor
noncardioembolic ischemic stroke (NIHSS score ≤3) who did not receive IV
alteplase, treatment with dual antiplatelet therapy with aspirin and
clopidogrel, started within 24 hours after symptom onset and continued
for 21 days is effective in reducing recurrent ischemic stroke up to 90
days from symptom onset. However, as the long-term risk of major
disabling bleeding with aspirin-based antiplatelet treatment is higher
in patients aged 75 years or older, routine co-prescription of proton
pump inhibitor should be encouraged.