Obesity and inflammatory markers effect on grafts blood flow in off-pump
coronary artery bypass - preliminary report.
Abstract
Background: Coronary artery bypass grafting is still a therapy of choice
for complex ischemic heart disease. The purpose of the study was to
compare the relation between obesity and blood flow through
aorto-coronary bypass grafts with coexisting preoperative inflammatory
state presented neutrophil-to-lymphocyte and platelets-to-lymphocyte
ratios in retrospective analysis. Methods: We analyzed 50 consecutive
patients (mean age 65 +/- 8) who underwent off-pump coronary artery
bypass grafting (OPCAB) in our department in 2018. Graft blood flow
measurements, as well as platelet-to-lymphocyte (PLR) and
neutrophil-to-lymphocyte (NLR) ratios were evaluated. Results: Obese
patients undergoing arterial revascularization were characterized by
statistically significant lower arterial grafts flow for RIMA
(p=0.0043), LIMA (p=0.0023) and RA (p=0.0214) with satisfactory medium
term (897 +/- 123 days) results. The chronic inflammatory parameters
including NLR and PLR were significantly differed between obese and
non-obese patients (p=0.0312 and p=0.0003, respectively) referred for
surgery. The inverse correlation between BMI and NLR (r=0.307) and
PLR(r=0.413) was noted. Conclusion: Obese patients referred for CABG
present a decreased graft blood flow velocity combined with an increased
neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio.