Objectives: Part I analyzes the clinical characteristics of JO-RRP and AO-RRP. Part II explores the influencing factors of surgical intervals. Methods: Part I: Clinical features were analyzed in 168 RRP patients (59 JO-RRP and 109 AO-RRP) diagnosed and treated in our hospital. Part II: The correlation of interoperative time with onset age, gender, Derkay anatomical score or surgical methods were analyzed in JO-RRP patients. Results: The interoperative time between operations in the JO-RRP group was 116.3±75.9 days, and in the AO-RRP group was 169.1±141.7 days (p<0.05). In the JO-RRP group, the CO2 laser treatment interval (186.2±140.1 days) was significantly longer than that of the microdebrider group (124.7±114.5 days) (p=0.011). Conclusions: 1. JO-RRP patients had higher Derkay score, higher surgical frequency and shorter surgical interval. 2. The surgical intervals lengthened with age and shortened with higher Derkay scores. CO2 laser surgery has the longest interoperative time.

Abstract Background：Recurrent respiratory papillomatosis (RRP) is recurring benign papillomatous lesions which still relies on repeated surgical treatment. However, there is no guidelines of surgical technique nowadays. Objectives: This retrospective cohort study aims to obtain a better understanding of RRP, and select the best surgical modality for RRP among microdebrider, CO2 laser and KTP laser. Study design: Retrospective cohort study. Methods: Medical records of 112 RRP patients treated at EYE&ENT Hospital of Fudan University from 2018 to 2021 were reviewed, with at least 6-month follow-up. Three treatment subgroups(microdebrider, CO2 laser and KTP laser) were analyzed within AO-RRP and JO-RRP populations respectively. Results: 112 patients (39 JO-RRP and 72 AO-RRP) and a total of 353 surgical procedures were included. Jo-RRP group had higher Derkay anatomical score(p<0.05), lower percentage of dysplasia and an earlier trend in recurrence(p<0.05) than Ao-RRP group. There were no significant differences among three surgical modalities on median treatment intervals(MTI) or survival curves(p>0.05), with the Jo-RRP MTI of the microdebrider(92.5[47.3~200]), CO2 laser(140[70~255]), KTP laser(90[62.3~221.3]), and Ao-RRP microdebrider(267.50[152.5,449.5]), CO2 laser(247.5[145.5,474.7]), KTP laser(107.5[68.3,330.5]). Conclusion and Significance: The Jo-RRP patients have more concomitant invasiveness, but less dysplasia than AO-RRP patients. Three surgical modalities appeare to be equally effective in management of Jo-RRP or AO-RRP. Key Words: Papillomatosis, surgery, treatment, recurrence, efficacy.

Purposes: To evaluate the instant auditory benefit of an adhesive bone conduction hearing aid (ADHEAR) on children with bilateral congenital microtia, especially the sound localization ability under unilateral and bilateral fitting. Methods: Twelve patients with bilateral congenital microtia aged from 6 to 17 were included in this study. Pure tone threshold under sound field, speech recognition threshold in quiet and sound localization abilities were tested and compared before and after wearing the device. The pure tone threshold test was additionally repeated for two different wearing method – adhesive or fixed with softband; the sound localization test was repeated for both unilateral and bilateral fitting. Correlation analysis was then conducted to find the influencing factors of sound localization improvement. Results: Significant auditory improvement were found: the average pure tone threshold (PTA) reduced by 24.8 (adhesive) and 27.3 dB HL (softband), with no significant difference between the two wearing methods. The speech recognition threshold also improved by 29.0 dB. As for sound localization abilities, no significant improvement was found under unilateral fitting; but half (6 of 12) of the patients were notably benefited from bilateral fitting. The improvement was found to be strong correlated with the patients’ unaided sound localization ability – those with poorer localization abilities tends to benefit more. Moreover, it was found that the sound localization improvement was also negatively related with the malformation degrees of the patients’ head. Summary: ADHEAR affords significant auditory benefits for children with bilateral congenital microtia, in terms of sound and speech perception. The sound localization abilities could be partly improved instantly by bilateral fitting, and the improvement is related with factors such as adaption and skull malformations.