Comparison of preemptive and non-preemptive renal transplant recipients
with diabetes in terms of coronary artery disease and long-term survival
Abstract
Background Patients with end-stage renal disease have an increased risk
of cardiac events. Although preemptive renal transplantation decreases
mortality that is associated with dialysis, coronary artery disease
remains as the primary cause of mortality even after transplantation. In
this context, diabetic patients are more prone to adverse cardiac
events. We aimed to compare the incidence of coronary artery disease and
long-term survival rates in preemptive and non-preemptive diabetic renal
transplantation recipients. Methods Diabetic patients with end-stage
renal disease who underwent coronary angiography before renal
transplantation were included retrospectively. These patients were
divided into two groups as preemptive and non-preemptive according to
transplantation strategy. Angiographic findings, particularly the
severity of coronary artery disease, were compared between the two
groups. Long-term all-cause mortality rates were also compared. Results
A total of 164 patients were included in the study. Of these patients,
125 (78%) were male, and the median age was 54 (Q1-Q3=45-59). The
extent of coronary artery disease, revascularization rates SYNTAX and
Gemini scores were similar between the two groups (all
p>0.05). During 4,8 years of follow-up was there was no
statistical difference in all-cause mortality rates
(HR=0.59,[0.20–0.71],p[log-rank]=0,33). Multivariate Cox
regression analysis revealed that only age and hyperlipidemia were
predictive of all-cause mortality (HR=1.03 [1.001-1.07], p=0.04 and
HR=2.75 [1.20-6.28], p=0.01 respectively) Conclusion The prevalence,
severity and revascularization rates of coronary artery disease were
similar between the preemptive and non-preemptive diabetic renal
transplant recipients. Also, there was no statistical difference in
all-cause mortality rates during long-term follow-up. Keywords Kidney,
coronary, diabetes, transplantation, preemptive What’s known? : Although
preemptive kidney transplantation is advantageous since dialysis is not
applied, cardiovascular diseases are the most important cause of
morbidity. What’s new: Comparison of patients with and without
preemptive transplantation in the diabetic patient group in terms of
coronary artery disease and survival has not been performed