Comparing clinical course and outcomes of hospitalized pregnant with
non-pregnant women with COVID-19 in Wuhan, China: a case-controlled
study
Abstract
Objective: To compare the clinical course and outcomes of hospitalized
pregnant and non-pregnant patients with coronavirus disease 2019
(COVID-19). Design: Retrospective, single centre and case-control study.
Setting: Renmin Hospital of Wuhan University, Wuhan, Hubei province,
China Population: SARS-CoV-2-infected hospitalized 31 pregnant and 124
non-pregnant patients diagnosed between 1 January 1 and 7 May, 2020;
final date of follow-up was Jul 8, 2020. Main outcomes and measures:
Demographic, clinical, laboratory, radiological, treatments and outcomes
were collected, analyzed and compared between the two groups. All
neonates received detection for SARS-CoV-2. Results: Pregnant patients
had higher leucocytes, neutrophil counts, C-reactive protein and lactate
dehydrogenase level, but lower lymphocyte counts. More pregnant patients
received antibiotic, corticosteroids and oxygen support. All seventeen
neonates had negative results of severe acute respiratory syndrome
coronavirus (SARS-CoV-2) without complications. All 31 pregnant and 124
non-pregnant patients, with similar clinical symptoms, intensive care
unit admission and complications, had been discharged. Conclusion:
Pregnant patients might have more obvious inflammatory response,
cellular immune deficiency and potential tissue necrosis, but similar
clinical manifestations and outcomes as compared with the non-pregnant
patients. No evidence of neonatal infections and complications had been
shown in this study. Timely and active management may be beneficial for
improving the outcomes of pregnant women with COVID-19 and the neonates.
Keywords: Coronavirus Disease 2019; COVID-19; Severe Acute Respiratory
Syndrome Coronavirus 2; SARS-CoV-2; Pregnant; Non-Pregnant. Tweetable
abstract: Pregnant women had more obvious inflammatory response,
cellular immune deficiency and potential tissue necrosis, but similar
clinical manifestations and outcomes.