The effect of soy and soy product supplementation on circulating
adiponectin and leptin concentration: A systematic review and
meta‐analysis of randomized controlled trials
Abstract
Background: Adiponectin is a well-known adipokines with
anti-inflammatory effects. Leptin is known as its effect on food intake
and energy. Here in present study we aimed to evaluate possible effect
of soy supplementation on circulating adiponectin and leptin. Methods:
Systematic search performed up to April 2020 in the following databases:
PubMed, Scopus and Cochrane. All RCTs which evaluated the effect soy
supplementation on adiponectin and leptin concentration were included.
Results: According to our analysis on 14 studies, in overall, soy
supplementation had significant effect on adiponectin concentration.
Furthermore, soy supplementation has no significant effect on serum
leptin concentration, but subgroup analysis showed significant increase
in leptin concentration in studies with doses more than 20 g/day of soy
supplementation. Conclusion: Soy supplementation has significant
increasing effect on adiponectin level. Whilst pooled effect size did
not show any significant effect of soy product supplementation on leptin
level.